Preparation method of PARP1 inhibitor intermediate

The invention provides a preparation method of a PARP1 inhibitor intermediate, which comprises the following steps: reacting 6-hydroxynicotinic acid with nitric acid, and then carrying out halogenation reaction, esterification reaction, hydrolysis reaction and the like to obtain the intermediate shown in the formula I. The method disclosed by the invention is low in synthesis cost and high in product yield, provides a new advantageous process route for synthesis of the PARP1 inhibitor, and has industrial popularization and application prospects. 本发明提供了一种PARP1抑制剂中间体的制备方法，包括6-羟基烟酸与硝酸反应后，经卤代反应、酯化反应、水解反应等制备得到式I所示中间体的步骤。本发明方法合成成本低，产物产率高，为PARP1抑制剂的合成提供了新的优势工艺路线，具工业化推广应用前景。