Method for detecting aripiprazole related substances

The invention belongs to the field of pharmaceutical analysis, and particularly relates to a method for detecting aripiprazole related substances, which adopts reversed-phase high performance liquid chromatography for gradient elution and calculates the content of the aripiprazole related substances by a main component self-contrast method. Wherein the chromatographic conditions are as follows: a chromatographic column is an octadecyl silane bonded silica gel chromatographic column, a detector is an ultraviolet detector or a diode array detector, the detection wavelength is 254nm, the column temperature is 30 DEG C, a mobile phase A is sodium dihydrogen phosphate aqueous solution-acetonitrile, a mobile phase B is water-acetonitrile, the flow velocity is 1.0 mL/min, and the sample injection volume is 20 mu L. The method provided by the invention is high in sensitivity, strong in specificity and good in durability, 10 known impurities in aripiprazole can be effectively monitored, and the separation degree among