Preparation method of tetraene acetate and sterol dehydrogenase

The invention provides a preparation method of tetraene acetate and sterol dehydrogenase, and belongs to the technical field of steroid hormone medicine preparation. The preparation method comprises the following steps: taking a compound I as an initial raw material, carrying out a dehydration elimi...

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Bibliographische Detailangaben
Hauptverfasser:	ZHANG JIE, WANG HONGFU, WANG YOUFU, CUI FENGFENG, LEI LINGZHI, LUO MIN, SHAO ZHENPING
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS STEROIDS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides a preparation method of tetraene acetate and sterol dehydrogenase, and belongs to the technical field of steroid hormone medicine preparation. The preparation method comprises the following steps: taking a compound I as an initial raw material, carrying out a dehydration elimination reaction to obtain a compound II, then directly carrying out an ethynylation reaction on the compound II to obtain a compound IV, or carrying out a 3-site etherification protection reaction on the compound II to obtain a compound III, and then carrying out an ethynylation reaction to obtain the compound IV. And then sequentially carrying out esterification reaction, bromination addition reaction, replacement elimination reaction and enzymatic dehydrogenation reaction to obtain the tetraene acetate. According to the method provided by the invention, the used starting raw materials are low in price, easy to obtain and stable, the technological process is simple and good in controllability, the cost is low, the