Aspergillus fumigatus monocarboxylic acid transporter MFSmt gene and application thereof

The Aspergillus fumigatus monocarboxylic acid transporter MFSmt gene reveals the effect of voriconazole in treatment of conditioned pathogen Aspergillus fumigatus: MFSmt gene deletion causes increase of the drug resistance of Aspergillus fumigatus to amphotericin B and increase of the sensitivity to voriconazole. The discovery prompts that in clinical treatment, if a medicine for deleting the MFSmt gene or reducing the expression protein quantity is applied, the medicine can be combined with voriconazole to have a more efficient sterilization effect, and meanwhile, the use of amphotericin B is avoided, so that the generation of medicine resistance is avoided. The method has important clinical value for effectively treating clinical aspergillus fumigatus infection, determining a treatment scheme and controlling drug-resistant strains. 该烟曲霉单羧酸转运蛋白MFSmt基因揭示了伏立康唑在治疗条件致病菌烟曲霉中发挥的作用：MFSmt基因缺失导致烟曲霉对两性霉素B耐药性增加、对伏立康唑敏感性增加。这个发现提示临床治疗中，若应用使MFSmt基因缺失或表达蛋白量下降的药物时可与伏立康唑联合应用将有更高效的杀菌效果，同时应避免两性霉素B的使用，以免产生耐药。这对有效治疗临床烟曲霉感染确定治疗方案