Crosslinked hyaluronic acids and uses thereof

The invention discloses cross-linked hyaluronic acid and application thereof. The cross-linked hyaluronic acid is formed by cross-linking an epoxy cross-linking agent and hyaluronic acid. The hyaluronic acid before cross-linking is a linear molecule with the weight-average molecular weight (Mw) of 10 kDa to 2200 kDa, the cross-linked hyaluronic acid has a three-dimensional network structure, the cross-linking degree of the cross-linked hyaluronic acid is 1 to 50 percent, and the viscosity of the cross-linked hyaluronic acid is 20 to 25000mPa. S. The cross-linked hyaluronic acid provided by the invention can form a three-dimensional network structure for protecting cells, and can better protect the skin from being damaged by particulate pollutants such as PM2.5. Moreover, the cross-linked hyaluronic acid disclosed by the invention has the effects of long-acting moisture retention, wrinkle improvement, collagen hyperplasia promotion and the like, so that the skin can be kept smooth for a long time, and wrinkles