Monoclonal antibody for resisting vWF/PF4 protein and application thereof

The invention discloses an anti-vWF/PF4 protein monoclonal antibody and application thereof, and relates to the anti-vWF/PF4 protein monoclonal antibody or an antigen binding fragment thereof, the monoclonal antibody or the antigen binding fragment thereof comprises a heavy chain variable region CDR...

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Bibliographische Detailangaben
Hauptverfasser: GAO LEI, CUI YIMIN, LI LONGTU, XIANG QIAN, MO WENYI, LIU ZHIYAN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses an anti-vWF/PF4 protein monoclonal antibody and application thereof, and relates to the anti-vWF/PF4 protein monoclonal antibody or an antigen binding fragment thereof, the monoclonal antibody or the antigen binding fragment thereof comprises a heavy chain variable region CDR1 shown as SEQ ID NO: 1, a heavy chain variable region CDR2 shown as SEQ ID NO: 2, and a heavy chain variable region CDR3 shown as SEQ ID NO: 3, the light chain variable region CDR1 is shown as SEQ ID NO: 1, the light chain variable region CDR2 is shown as SEQ ID NO: 5, and the light chain variable region CDR3 is shown as SEQ ID NO: 6. The invention also provides a nucleotide molecule for coding the monoclonal antibody or the antigen binding fragment thereof, a vector, a host cell, a method and application. The invention also provides products, compositions and derivatives comprising the monoclonal antibodies of the invention or antigen-binding fragments thereof. 本发明公开了一种抗vWF/PF4蛋白的单克隆抗体及其应用,涉及抗vWF/PF4蛋白的单克隆抗体或其抗原结