Novel antibacterial peptide based on MCR-1 protein and application thereof

The invention discloses a novel antibacterial peptide based on MCR-1 protein and application of the novel antibacterial peptide. The sequence of the antibacterial peptide is as shown in SEQ ID NO. 1 or SEQ ID NO. 2. The synthetic length of the antibacterial peptide is short, the production cost can be greatly reduced, and meanwhile, the immunogenicity and cytotoxicity of the antibacterial peptide can be effectively reduced. Experiments also prove that the two small molecule peptides can be combined with and destroy bacterial cell membranes to play a role, and have broad-spectrum antibacterial activity in vivo and in vitro. The antibacterial oligopeptide provided by the invention can act synergistically with colistin, significantly improves the antibacterial activity of colistin, can be used in combination, and provides a new therapeutic scheme for treatment of colistin drug-resistant bacterial infection. 本发明公开了一种基于MCR-1蛋白的新型抗菌肽及其应用。所述抗菌肽的序列如SEQ ID NO.1或SEQ ID NO.2所示。本发明的抗菌肽的合成长度较短，不但可以大大缩减生产成本，同时也能有效降低抗菌肽的免疫原