Synthesis method of tembotrione intermediate

The invention belongs to the field of chemical industry, and discloses a tembotrione intermediate synthesis method, which comprises: 1) carrying out a Friedel-Crafts acylation reaction on a raw material 2-methyl-3-chloroanisole sulfide and methyl chloroformate to obtain 3-methyl-2-chloro-4-methylthi...

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Bibliographische Detailangaben
Hauptverfasser: TAO MING, ZHU HANG, TAO XIAOMIN, YUAN JIXIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the field of chemical industry, and discloses a tembotrione intermediate synthesis method, which comprises: 1) carrying out a Friedel-Crafts acylation reaction on a raw material 2-methyl-3-chloroanisole sulfide and methyl chloroformate to obtain 3-methyl-2-chloro-4-methylthio methyl benzoate, and carrying out a Friedel-Crafts acylation reaction on the 3-methyl-2-chloro-4-methylthio methyl benzoate to obtain 3-methyl-2-chloro-4-methylthio methyl benzoate; (2) oxidizing the methyl 3-methyl-2-chloro-4-(methylthio) benzoate, so as to obtain methyl 3-methyl-2-chloro-4-(methylsulfonyl) benzoate; and (3) carrying out bromination on the 3-methyl-2-chloro-4-methylsulfonyl methyl benzoate, so as to obtain the 2-chloro-3-bromomethyl-4-methylsulfonyl methyl benzoate which is used as a target product. The method has the technical advantages of simple process, high yield and the like. 本发明属于化工领域,公开了一种环磺酮中间体的合成方法,包括以下步骤:1)、由2-甲基-3-氯茴香硫醚为原料,与氯甲酸甲酯进行傅克酰基化反应,得到3-甲基-2-氯-4-甲硫基苯甲酸甲酯;2)、3-甲基-2-氯-4-甲硫基苯甲酸甲酯经