Dapagliflozin and metformin sustained release tablet and preparation method thereof

The invention provides a dapagliflozin and metformin sustained-release tablet. The dapagliflozin and metformin sustained-release tablet sequentially comprises a metformin hydrochloride sustained-release pellet core, an isolating layer, a dapagliflozin layer and a film coating layer from inside to ou...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SHIM JAE-KWAN, ZHENG LINHAI
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention provides a dapagliflozin and metformin sustained-release tablet. The dapagliflozin and metformin sustained-release tablet sequentially comprises a metformin hydrochloride sustained-release pellet core, an isolating layer, a dapagliflozin layer and a film coating layer from inside to outside, wherein the metformin hydrochloride sustained-release pellet core is prepared from metformin hydrochloride, an adhesive I, a sustained-release material, a lubricating agent I and a filling agent; and the dapagliflozin layer comprises dapagliflozin propylene glycol monohydrate, an adhesive II and a lubricant II. The invention provides the dapagliflozin and metformin sustained-release tablet, the dapagliflozin and metformin sustained-release tablet is prepared by combining the dapagliflozin and metformin and combining a controlled-release pellet technology, and the dapagliflozin and metformin sustained-release tablet is prepared by reasonably compounding various components, is high in uniformity and good in su