Method for removing organic solvent in bupivacaine liposome preparation process

The invention discloses a method for removing an organic solvent in a bupivacaine liposome preparation process. The method comprises the following specific steps: S1, preparing multiple emulsion; s2, removing the organic solvent in the multiple emulsion through spray drying equipment; the temperature of the multiple emulsion is set to be 20-45 DEG C, the flow velocity is 5-10 L/min, and the organic solvent can reach 100 ppm or below after two cycles; and S3, carrying out ultrafiltration replacement on the external water phase solution to obtain a bupivacaine liposome finished product. According to the method, the organic solvent in the solution is removed by using the existing spray drying equipment, and the maturity and safety of the equipment are highly guaranteed after being used for many years and many projects; spray drying equipment is mature equipment and does not need to be additionally designed aiming at a project, so that the influence of the design of the equipment on the product is not worried in