Application of m5C methylation regulatory factors DNMT1 and NSun2 in tumors

The invention provides an application of m5C methylation regulatory factors DNMT1 and NSun2 in tumors, wherein the regulatory factors comprise DNMT1 and/or NSun2. The invention finds that DNMT1 mediated gene promoter region methylation and NSun2 mediated mRNA methylation coordinate to regulate osteosarcoma cell apoptosis; the DNMT1 is used for inhibiting the expression of the NSun2 through a promoter region of the methylated NSun2; the DNMT1 and the NSun2 are used for regulating and controlling anti-apoptosis genes AXL, NOTCH2 and YAP1 through DNA (Deoxyribose Nucleic Acid) methylation and mRNA (Messenger Ribonucleic Acid) methylation respectively. When the anti-apoptosis genes are exposed to cis-platinum or adriamycin, DNMT1 is increased, NSun2 is inhibited, promoter methylation of the anti-apoptosis genes is enhanced, mRNA methylation is weakened, expression of the anti-apoptosis genes is greatly reduced, and therefore osteosarcoma cells are subjected to apoptosis. 本发明提供一种m5C甲基化调节因子DNMT1、NSun2在肿瘤中的应用，所述调节因子