Acetylcysteine injection and preparation method thereof

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses an acetylcysteine injection and a preparation method thereof. Comprising the following steps: adding water for injection accounting for 40-70% of the total preparation volume and disodium edetate...

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Bibliographische Detailangaben
Hauptverfasser: LI QINGRAN, ZHANG ZEHUI, LIU XIAOJUAN, CUI YANJIE, LIU CHUAN, LI CONG, WANG BO, YAN YONGNA
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention relates to the technical field of pharmaceutical preparations, and particularly discloses an acetylcysteine injection and a preparation method thereof. Comprising the following steps: adding water for injection accounting for 40-70% of the total preparation volume and disodium edetate accounting for the prescription dosage into a preparation tank, uniformly mixing to obtain a disodium edetate solution, then adding acetylcysteine accounting for the prescription dosage, stirring and dissolving, then adjusting the pH value to 6.8-7.2, supplementing the water for injection to the total preparation volume to obtain acetylcysteine liquid medicine, and filling the acetylcysteine liquid medicine with the injection water. Then filtering through a multi-stage polyether sulfone filter element of which the pore diameter is sequentially reduced, filling nitrogen, controlling the headspace residual oxygen content in a filling container to be less than 3% after filling, sealing, sterilizing, carrying out lamp