CFTR MODULATOR COMPOUNDS, COMPOSITIONS AND USES THEREOF

The present invention provides CFTR modulator compounds and compositions comprising the compounds. The invention also provides compounds that inhibit PDE4 and compositions comprising the compounds. The invention also provides methods of using the compounds and compositions to modulate CFTR, methods of treating ocular diseases or disorders, and methods of treating CFTR-related indications. The invention also provides methods of using the compounds and compositions to inhibit PDE4, treat inflammatory diseases or disorders, and treat other PDE4-related indications. The invention also provides methods for preparing the compounds and compositions, and synthetic precursors of the compounds. 本发明提供了CFTR调节剂化合物和包含所述化合物的组合物。本发明还提供了抑制PDE4的化合物和包含该化合物的组合物。本发明还提供了使用所述化合物和组合物以调节CFTR的方法、治疗眼部疾病或疾患的方法和治疗CFTR相关适应症的方法。本发明还提供了使用所述化合物和组合物以抑制PDE4、治疗炎性疾病或疾患和治疗其他PDE4相关适应症的方法。本发明还提供了所述化合物和组合物的制备方法，和所述化合物的合成前体。