Co-amorphous substance of free alkali or hydrochloride of pyrimidine derivative 1D228 and dispersing agent as well as preparation method and application of co-amorphous substance

The invention belongs to the technical field of medicines, and particularly relates to a co-amorphous substance of free alkali or hydrochloride of a pyrimidine derivative 1D228 and a dispersing agent as well as a preparation method and application of the co-amorphous substance. The invention provides a co-amorphous substance of free base or hydrochloride of pyrimidine derivative 1D228 and a dispersing agent, wherein the dispersing agent comprises polyvinylpyrrolidone or hydroxypropyl methyl cellulose. After the 1D228 free alkali and polyvinylpyrrolidone form a co-amorphous form, the solubility of the 1D228 free alkali in water is increased, and the 1D228 free alkali and polyvinylpyrrolidone do not need to be salified with acid, so that the preparation and clinical use of a 1D228 preparation can be met. The 1D228 hydrochloride and the polyvinylpyrrolidone form a co-amorphous form, and the solubility of the 1D228 in water is also increased. In addition, the co-amorphous form of the free alkali or hydrochloride