Preparation method of amorphous apattamide

The invention discloses a preparation method of amorphous apattamide, which comprises the following steps: (1) adding a compound I into an alcohol solution of methylamine, and reacting for 18-30 hours at-15-0 DEG C; (2) after the reaction is finished, adding an organic solvent and an acidic quenching agent, adjusting the pH value of the system to 2-4, and layering to obtain an organic phase; and (3) washing the organic phase with water for 1-3 times, and directly carrying out spray drying to obtain the amorphous apattamide. 本发明公开了一种无定形阿帕他胺的制备方法，所述制备方法包括步骤：(1)将化合物I加入到甲胺的醇类溶液中，-15～0℃反应18～30小时；(2)反应结束后，加入有机溶剂和酸性淬灭剂，调节体系pH为2～4，分层得到有机相；(3)有机相用水洗涤1～3次，直接进行喷雾干燥，获得无定型阿帕他胺。