Protein tyrosine phosphatase inhibitors and methods of use thereof

The invention relates to protein tyrosine phosphatase inhibitors and methods of use thereof. Provided herein are compounds, compositions and methods useful for inhibiting protein tyrosine phosphatase, such as type 2 non-receptor protein tyrosine phosphatase (PTPN2) and/or type 1 non-receptor protein tyrosine phosphatase (PTPN1), and for treating related diseases, disorders and conditions, such as cancer or metabolic diseases, that are positively responsive to treatment with PTPN1 or PTPN2 inhibitors. 本发明涉及蛋白酪氨酸磷酸酶抑制剂及其使用方法。本文提供了可用于抑制蛋白酪氨酸磷酸酶，例如2型非受体蛋白酪氨酸磷酸酶(PTPN2)和/或1型非受体蛋白酪氨酸磷酸酶(PTPN1)，以及用于治疗积极响应于PTPN1或PTPN2抑制剂治疗的相关疾病、病症和疾患，例如癌症或代谢疾病的化合物、组合物和方法。