Preparation method of aryl nitrile compound

Preparation method of aryl nitrile compound

The invention discloses a preparation method of an aryl nitrile compound. The preparation method of the compound II provided by the invention comprises the following step: in water and an organic solvent, carrying out cyanidation reaction on a compound I, palladium salt, K4 [Fe (CN) 6]. 3H2O and a p...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SUN QIAO, WANG XIAOWEI, YAO LIANBIN, ZHU JINGYANG
Format: Patent
Sprache:chi ; eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention discloses a preparation method of an aryl nitrile compound. The preparation method of the compound II provided by the invention comprises the following step: in water and an organic solvent, carrying out cyanidation reaction on a compound I, palladium salt, K4 [Fe (CN) 6]. 3H2O and a phosphine ligand to obtain the compound shown in the formula II. According to the preparation method disclosed by the invention, the compound II can be obtained by controlling the purity and the yield in a relatively high intermediate process. 本发明公开了一种芳基腈类化合物的制备方法。本发明提供的化合物II的制备方法包括以下步骤：水和有机溶剂中，化合物I、钯盐、K4[Fe(CN)6].3H2O、膦配体发生氰化反应，得到式II化合物。本发明的制备方法能够以较高的中间过程控制纯度和收率得到化合物II。