Application of isoliquiritigenin in preparation of medicine for preventing or treating drug-induced liver injury caused by acetaminophen

The invention relates to novel application of isoliquiritigenin, in particular to application of licorice extract isoliquiritigenin to prevention and treatment of acute liver injury induced by acetaminophen. The invention provides an application of isoliquiritigenin in improvement of APAP induced liver injury. An animal and cell in-vivo and in-vitro combined model is adopted to fully prove that the isoliquiritigenin can obviously improve the APAP-induced liver injury, and the protection effect is related to the anti-apoptosis and anti-oxidative stress capabilities of the isoliquiritigenin. And a basis is provided for taking the isoliquiritigenin as a novel medicine for preventing or treating the APAP liver injury. And meanwhile, beneficial exploration and attempt are made for research and development of medicines for treating drug-induced liver injury by traditional Chinese medicines. 本发明涉及异甘草素的新用途，具体是甘草提取物异甘草素对对乙酰氨基酚诱导的急性肝损伤的具有潜在的预防和治疗作用。本发明提出了异甘草素在改善APAP诱导的肝损伤中的应用。采用动物及细胞体内外相结合的模型充分证明异甘草素可以显著改善APAP诱导的肝损伤，且这