Anti-beta cytokine antibodies, fragments thereof and multispecific binding molecules

Anti-beta cytokine antibodies, fragments thereof and multispecific binding molecules

The present disclosure provides anti-BTC antibodies, methods of producing the antibodies, pharmaceutical compositions comprising the antibodies, and methods of using the antibodies. The disclosure also provides multispecific binding molecules, e.g., bispecific antibodies, comprising a BTC binding mo...

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Hauptverfasser: STEFANIDAKIS MARGARITA, BIGELOW CHAD E, NGUYEN ANH ANH, MOCK NICOLAI, CLARK KERRY L, GHOSH JUDIT G, CHASTAIN JAMES E, HANKS SCOTT M, RANGASWAMY NARASIMHA V, POOLE STEPHEN H, IYER GANESH R, HAUBST NICOLE, ETMAD-GILBERTSON BRIAN A, CARRION ARIEL M, TOCSOZ ELENA, QIU YUPING, TWAROG MD Z
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present disclosure provides anti-BTC antibodies, methods of producing the antibodies, pharmaceutical compositions comprising the antibodies, and methods of using the antibodies. The disclosure also provides multispecific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety. 本披露提供了抗BTC抗体，产生所述抗体的方法，包含所述抗体的药物组合物，以及使用所述抗体的方法。本披露还提供了包含BTC结合部分和抗VEGF结合部分的多特异性结合分子，例如，双特异性抗体。