Pyrazolyl-pyrimidine derivatives as kinase inhibitors

The present invention relates to pyrazolyl-pyrimidine derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as therapeutic agents. These compounds are kinase inhibitors, in particular spleen tyrosine kinase (SYK), and are useful in the treatment of cancer, cell proliferative disorders, viral infections, immune disorders, neurodegenerative disorders, and cardiovascular diseases. 本发明涉及吡唑基-嘧啶衍生物、其制备方法、包含它们的药物组合物以及它们作为治疗剂的用途。这些化合物是激酶抑制剂，特别是脾酪氨酸激酶(SYK)的抑制剂，并且可用于治疗癌症、细胞增殖性紊乱、病毒感染、免疫紊乱、神经退行性紊乱和心血管疾病。