PNA probes for pre-targeted imaging and therapy

The present invention relates to a kit for targeting a diagnostic or therapeutic agent to a target site, comprising: (a) a first conjugate comprising (i) a targeting moiety capable of selectively binding to the target site; and (ii) a first hybridization probe portion comprising a PNA oligomer; and (b) a second conjugate comprising (i) a second hybridization probe moiety comprising a complementary PNA oligomer; and (ii) a diagnostic or therapeutic moiety; wherein the length of the complementary PNA oligomer in the second hybridization probe portion does not exceed 14 bases. The invention also relates to methods for delivering a diagnostic or therapeutic agent to a target site in a mammal, and methods for diagnosing or treating a medical condition in a mammal, such as, for example, cancer. 本发明涉及用于将诊断或治疗剂靶向至靶位点的试剂盒，包括：(a)第一缀合物，包括(i)能够选择性地与靶位点结合的靶向部分；和(ii)包括PNA低聚物的第一杂交探针部分；和(b)第二缀合物，包括(i)包括互补的PNA低聚物的第二杂交探针部分；和(ii)诊断剂或治疗剂部分；其中，在第二杂交探针部分中的互补PNA低聚物的长度不超过14个碱基。本发明还涉及用于向哺乳动物的靶位点递送诊断或治疗剂的方法，以及用于诊断或治疗哺乳动物的医学病症，诸如例如癌症的方