Recombinant bacillus erysipelatos suis surface antigen SpaA protein and application thereof

The invention discloses a recombinant bacillus erysipelatos suis surface antigen SpaA protein and application thereof.The coding gene of the recombinant bacillus erysipelatos suis surface antigen SpaA protein adopts a wild type sequence with high conservative property, has good safety, immunogenicity and cross-serotype protection effect, can generate an antibody with enough immune protection force, and can be used for preparing the recombinant bacillus erysipelatos suis surface antigen SpaA protein. The method has a good application value for establishing a swine erysipelas related antigen and antibody diagnosis method. Meanwhile, the protein has good immunocompatibility when being mixed with other antigens, and can provide sufficient dosage space for other components. 本发明公开了一种重组猪丹毒杆菌表面抗原SpaA蛋白及其应用，该重组猪丹毒杆菌表面抗原SpaA蛋白的编码基因采用具有高度保守性的野生型序列，具备良好的安全性、免疫原性、跨血清型保护效果，可产生具有足够免疫保护力抗体，对于猪丹毒相关抗原及抗体诊断方法建立均具有较好的应用价值。同时该蛋白与其他抗原混合时具备良好的免疫相容性，能够为其他组分提供充足的剂量空间。