Cholesterol derivative and liposome with mitochondrial targeting function as well as preparation method and application of cholesterol derivative and liposome

The invention relates to the field of biological materials, and discloses a cholesterol derivative and liposome with a mitochondrial targeting function as well as a preparation method and application of the cholesterol derivative and liposome. The structural formula of the cholesterol derivative is shown in the following formula (1). The cholesterol derivative can be assembled with phospholipid to form lipidosome which is used for targeted delivery of drugs and can promote enrichment of the drugs in mitochondria. 本发明涉及生物材料领域，公开了一种具有线粒体靶向功能的胆固醇衍生物和脂质体及其制备方法和应用。所述胆固醇衍生物的结构式如以下式(1)所示。该胆固醇衍生物可与磷脂组装成脂质体，用于药物的靶向递送，可促使药物在线粒体富集。