Dotegravir-m-hydroxybenzoic acid eutectic crystal as well as preparation method and application thereof

The invention provides a dotegravir-m-hydroxybenzoic acid eutectic crystal and a preparation method and application thereof, the dotegravir-m-hydroxybenzoic acid eutectic crystal is formed by combining dotegravir and m-hydroxybenzoic acid according to a molar ratio of 1: 1, the molecular formula is C27H25F2N3O8, and the relative molecular mass is 557.50. As a novel crystal form, the dotegravir-m-hydroxybenzoic acid eutectic provided by the invention can improve the dissolution rate of dotegravir under the condition of not changing covalent bonds of dotegravir, so that the drug effect and bioavailability are improved. The dotegravir-m-hydroxybenzoic acid eutectic is prepared by adopting a grinding reaction crystallization method or a suspension reaction crystallization method, and the method is simple in process, mild in condition, good in repeatability, green, environmentally friendly and suitable for large-scale production. 本发明提供了一种多替拉韦-间羟基苯甲酸共晶及其制备方法和应用，所述多替拉韦-间羟基苯甲酸共晶是由多替拉韦和间羟基苯甲酸按照摩尔比1:1结合而成，分子式为C27H25F2N