Intermediate for synthesizing dextromethorphan as well as preparation method and application of intermediate

The invention provides an intermediate for synthesizing dextromethorphan as well as a preparation method and application of the intermediate. The chemical structure of the intermediate is shown as a formula 10. The invention discloses the compound 10 for the first time, and the compound is used for...

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Bibliographische Detailangaben
Hauptverfasser: CHEN ZHONGHU, YU SHUAI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides an intermediate for synthesizing dextromethorphan as well as a preparation method and application of the intermediate. The chemical structure of the intermediate is shown as a formula 10. The invention discloses the compound 10 for the first time, and the compound is used for preparing dextromethorphan, so that not only is the yield improved, but also the purity is improved. According to the novel synthesis route, expensive starting materials are not used, reaction conditions are mild, and industrial production is facilitated. 本发明提供了一种合成右美沙芬的中间体及其制备方法与应用。所述中间体的化学结构如式10所示:本发明首次公开了化合物10并将该化合物用于制备右美沙芬,不仅提高了收率,而且提高了纯度。本发明的合成新路线不使用昂贵的起始物料,且反应条件较为温和,有利于工业化生产。