Antibacterial and antioxidant composite nanofiber scaffold and preparation method thereof

The invention discloses an antibacterial and antioxidant composite nanofiber scaffold and a preparation method thereof. The scaffold is a polycaprolactone/gelatin electrostatic spinning scaffold loaded with CuNPs (at) MBG-THC nanoparticles. The copper ions released by the copper nanoparticles are used for inhibiting bacterial proliferation at the wound, excessive ROS (reactive oxygen species) at the wound is removed through release of the important active components tetrahydrocurcumin and mesoporous active glass, fibroblast proliferation, collagen deposition, extracellular matrix accumulation and angiogenesis can be effectively promoted, and rapid healing of the wound is facilitated. 本发明公开了一种抗菌抗氧化的复合纳米纤维支架及其制备方法，该支架为负载CuNPs@MBG-THC纳米颗粒的聚己内酯/明胶静电纺丝支架。本发明利用铜纳米颗粒释放的铜离子抑制伤口处的细菌增殖，通过重要活性成分四氢姜黄素和介孔活性玻璃的释放，清除伤口处过量的ROS，并能有效促进成纤维细胞增殖，胶原沉积，细胞外基质积累和血管生成的，有利于伤口的快速愈合。