Medical hydrogel, preparation method and application of medical hydrogel in preparation of vascular leakage sealing agent

The invention belongs to the technical field of medical materials, and relates to medical hydrogel, a preparation method and application of the medical hydrogel in preparation of a vascular leakage sealing agent. The raw materials comprise a first component, a second component and a third component,...

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Bibliographische Detailangaben
Hauptverfasser: XIA YIRAN, DENG FENGJUAN, ZOU FANGMING, BAI HUAN, ZHAO CHENGRU, ZHANG ZAIQING, ZHANG CHUNXIA, ZOU FANGZHAO
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of medical materials, and relates to medical hydrogel, a preparation method and application of the medical hydrogel in preparation of a vascular leakage sealing agent. The raw materials comprise a first component, a second component and a third component, the first component is multi-arm polyethylene glycol activated ester, the second component is a first cross-linking agent, and the third component is a second cross-linking agent; the first cross-linking agent is an amino or sulfydryl-terminated multi-arm polyethylene glycol derivative, and the second cross-linking agent is polyethyleneimine and/or polylysine; the chemical structural formula of the multi-arm polyethylene glycol activated ester is amino or sulfydryl-terminated multi-arm polyethylene glycol derivative, R1 and R2 are independently selected from R3 which is primary amino or sulfydryl, x is an integer of 1-250, y is an integer of 3-8, z is an integer of 1-250, p and p'are integers of 2-8, and the mass