Application of targeting CCDC25 in preparation of medicine for treating and/or preventing organ fibrosis induced by chemotherapy

The invention belongs to the technical field of biological medicines, and discloses application of targeted CCDC25 in treatment and/or prevention of organ fibrosis induced by chemotherapy. The CCDC25 inhibitor is applied to preparation of the medicine for treating and/or preventing organ fibrosis or myocardial atrophy induced by chemotherapy. In a CCDC25 gene knockout mouse model, it is found that CCDC25 can serve as a target spot for treating organ fibrosis induced by chemotherapy, a foundation is laid for the CCDC25 inhibitor serving as a medicine for reducing organ fibrosis or myocardial atrophy induced by chemotherapy to enter clinical research, and a thought and a theoretical basis are provided for development of subsequent related clinical tests. 本发明属于生物医药技术领域，公开了一种靶向CCDC25在治疗和/或预防化疗诱导的器官纤维化中的应用。本发明将CCDC25抑制剂应用于制备治疗和/或预防化疗诱导的器官纤维化或心肌萎缩的药物。本发明在CCDC25基因敲除小鼠模型中发现，CCDC25可作为治疗化疗诱导的器官纤维化的靶点，为CCDC25抑制剂作为降低化疗诱导器官纤维化或心肌萎缩的药物进入临床研究奠定了基础，为后续相关临床试验的开展提供了思路及理论依据。