Alprimilast pharmaceutical composition and preparation method thereof

The invention relates to the technical field of medicines, in particular to an alprimilast pharmaceutical composition and a preparation method thereof. The composition is mainly composed of 30-40 parts of alpramilast solid dispersion, 50-65 parts of a filler, 2-4 parts of a disintegrating agent and...

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Bibliographische Detailangaben
Hauptverfasser: QI FENG, MA YANDI, LIU ALI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to the technical field of medicines, in particular to an alprimilast pharmaceutical composition and a preparation method thereof. The composition is mainly composed of 30-40 parts of alpramilast solid dispersion, 50-65 parts of a filler, 2-4 parts of a disintegrating agent and 0.5-2 parts of a lubricant, prepared alpramilast solid dispersion particles are sieved and then directly mixed with other auxiliary materials for tabletting to prepare tablets, the problem of poor dissolution of alpramilast is solved, and the content of alpramilast is improved. And the bioavailability of the medicinal preparation and the absorption of the body to the medicine can be improved. Compared with an original commercially available product, the product obtained by the method disclosed by the invention has the same release behavior, and the product is relatively good in release uniformity, stable in quality, low in production cost and beneficial to industrial production. 本发明涉及医药技术领域,具体涉及一种阿普米司特药物组合物及其制备方法。所