Preparation method of compound with cyclopropane lactone structure and preparation method of artificially synthesized DNA metalloenzyme

The invention discloses a preparation method of a compound with a cyclopropane lactone structure and a preparation method of an artificially synthesized DNA metalloenzyme, and the method comprises the following steps: by taking allyl diazoester as a raw material, carrying out catalytic cyclopropanation reaction to prepare the compound with the cyclopropane lactone structure; the catalyst for catalyzing the cyclopropanation reaction is artificially synthesized DNA metalloenzyme; the artificially synthesized DNA metalloenzyme is an artificial G quadruplex DNA metalloenzyme, and the valence state of metal elements in the artificially synthesized DNA metalloenzyme is + 2. According to the present invention, the intramolecular cyclopropanation reaction is successfully and selectively catalyzed with the high enantiomer by using the artificial G-quadruplex DNA metalloenzyme so as to obtain the cyclopropane gamma lactone structure; the reaction is carried out in a water phase, the reaction condition is mild, no pollu