Stable multi-dose GLP-1 receptor stimulant preparation and preparation method and application thereof

Stable multi-dose GLP-1 receptor stimulant preparation and preparation method and application thereof

The present invention relates to the field of medicine, and particularly discloses a stable multi-dose administration GLP-1 receptor agonist pharmaceutical preparation, the preparation comprises a stabilizer, and the stabilizer is selected from reduced glutathione or/and ergothioneine, preferably re...

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Bibliographische Detailangaben
Hauptverfasser: CAO CHUNLAI, WU WENYING, HOU QINGHONG, QIN XIAOTING, KUANG YILONG, LIU HEDONG, LONG YANQING, CHEN PEICHUN, ZHOU CUI, CHEN KAIZAO, FENG LIFANG, HE XIUYI, XIANG XIUXUE, CHEN LIRU, LUO YUNSI
Format: Patent
Sprache:chi ; eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The present invention relates to the field of medicine, and particularly discloses a stable multi-dose administration GLP-1 receptor agonist pharmaceutical preparation, the preparation comprises a stabilizer, and the stabilizer is selected from reduced glutathione or/and ergothioneine, preferably reduced glutathione. The preparation has the advantages of high stability, no color change after illumination, higher clinical safety and the like. 本发明涉及医药领域，具体公开了一种稳定的多剂量给药的GLP-1受体激动剂的药物制剂，所述制剂包含稳定剂，其中所述稳定剂选自还原型谷胱甘肽或/和麦角硫因，优选还原型谷胱甘肽。本发明制剂具有稳定性高、光照后不变色、临床安全性更高等优点。