PI3K-alpha inhibitors and methods of use thereof

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods of inhibiting P13K-alpha enzyme activity using the compounds and compositions of the present disclosure. The present disclosure further relates to, but is not limited to, methods of treating conditions associated with PI3K-alpha signaling with the compounds and compositions of the present disclosure. 本公开涉及新颖化合物和其药物组合物，以及用本公开的所述化合物和组合物抑制P13K-α酶活性的方法。本公开进一步涉及但不限于用本公开的所述化合物和组合物治疗与PI3K-α信号传导相关的病症的方法。