Compounds and their use in treatment of cancer

The present specification relates generally to compounds having formula (I): and pharmaceutically acceptable salts thereof, wherein A, Z, Y, RA, linker, and v have any meanings defined herein. The specification also relates to the use of such compounds and pharmaceutically acceptable salts thereof i...

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Bibliographische Detailangaben
Hauptverfasser: GRABNER CHRISTIAN, J. G. KEITEL, BJU SSEN UWE, FALLON CHRISTOPHER, PERRY MICHAEL WILLIAM DAVID, I. N. MICHELDES, CURLEY GARY W, STORER ROBERT I, HEIJL THEODORUS GERARDUS CORNELIS, BAGAL SHARANJEET KUMAR
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The present specification relates generally to compounds having formula (I): and pharmaceutically acceptable salts thereof, wherein A, Z, Y, RA, linker, and v have any meanings defined herein. The specification also relates to the use of such compounds and pharmaceutically acceptable salts thereof in methods of treating the human or animal body, for example in the prevention or treatment of cancer. The specification also relates to processes and intermediate compounds involved in the preparation of such compounds, and to pharmaceutical compositions containing such compounds. 本说明书总体上涉及具有式(I)的化合物:及其药学上可接受的盐,其中A、Z、Y、RA、接头和v具有本文定义的任何含义。本说明书还涉及此类化合物及其药学上可接受的盐在治疗人体或动物体的方法中,例如在预防或治疗癌症中的用途。本说明书还涉及参与制备此类化合物的方法和中间体化合物,并且涉及含有此类化合物的药物组合物。