Chiral binuclear Ir (III) metal-organic double helix structure compound as well as preparation method and application thereof

The invention discloses a chiral binuclear Ir (III) metal-organic double helix structure compound as well as a preparation method and application thereof, and belongs to the technical field of drug synthesis. According to the preparation method, chiral mononuclear Ir (III) complexes L1 and L2 are us...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: YAO YOUGANG, LI XUEZHAO, ZHANG RONG
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention discloses a chiral binuclear Ir (III) metal-organic double helix structure compound as well as a preparation method and application thereof, and belongs to the technical field of drug synthesis. According to the preparation method, chiral mononuclear Ir (III) complexes L1 and L2 are used as construction units, and the chiral mononuclear Ir (III) complexes L1 and L2 and chiral corresponding cyclohexanediamine are respectively constructed to obtain the chiral metal-organic helical structures L1-i-D1 and L2-i-D2. The binuclear Ir (III) chiral metal-organic double helix structure compound prepared by the invention has excellent photophysical properties, good biocompatibility and capability of sensitizing oxygen to generate singlet oxygen. Meanwhile, a plurality of hydrogen bond binding sites can enhance the binding performance of the helical structure and DNA. Results show that the combining capacities of different chiral helical structures and DNA have obvious differences, cancer cells are destroye