Continuous synthesis process of N-benzyl hydroxylamine hydrochloride

The invention discloses a continuous synthesis process of N-benzyl hydroxylamine hydrochloride, which comprises the following steps: firstly preparing a material A and a material B, then preheating the obtained material A through a preheating module by adopting a continuous reactor, mixing the mater...

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Hauptverfasser: TAN YUE, LU CAIYANG, ZHANG YING, CAI GUOXIAN, CHEN KE, CHEN XIAOGUANG, YANG HUA
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a continuous synthesis process of N-benzyl hydroxylamine hydrochloride, which comprises the following steps: firstly preparing a material A and a material B, then preheating the obtained material A through a preheating module by adopting a continuous reactor, mixing the material A with the material B for reaction in a reaction module, and collecting reaction liquid; adjusting the pH value of the reaction liquid, and concentrating and recovering the organic solvent to obtain a solid reactant; dissolving the obtained solid reactant, and extracting with an organic solvent to obtain an organic phase and a water phase; concentrating the organic phase again to obtain an N-benzyl hydroxylamine hydrochloride crude product and a water phase, and purifying the crude product to obtain N-benzyl hydroxylamine hydrochloride; and the water phase can be directly used as a salt of a raw material hydroxylamine in the next batch of experiments and is used for preparing a material B. According to the synt