Mepivacaine hydrochloride liposome and preparation method thereof

The preparation method comprises the following steps: mixing and dissolving ammonium sulfate with water to obtain an ammonium sulfate solution, mixing and dissolving disaccharide and a buffer agent with water to obtain a buffer protection solution, and mixing and dissolving mepivacaine hydrochloride with water to obtain a mepivacaine hydrochloride solution; the preparation method comprises the following steps: mixing and dissolving phospholipid, cholesterol and a surfactant in an organic solvent to obtain an oil-phase solution, and removing the organic solvent to obtain a mixed oil-phase auxiliary material; adding the oil-phase auxiliary material into an ammonium sulfate solution, and hydrating to obtain a hydrated solution; the preparation method comprises the following steps: hydrating a mepivacaine hydrochloride solution to obtain a hydrated solution, granulating the hydrated solution to obtain a blank liposome, replacing an external water phase of the liposome with a buffer protection solution to obtain a