Programmed cell necrosis inhibitor as well as preparation method and application thereof

The invention provides a programmed cell necrosis inhibitor as well as a preparation method and application thereof. Specifically, the invention provides a compound, or pharmaceutically acceptable salts, hydrates or solvates thereof, and the compound is as shown in a formula I in the specification. The invention also provides a preparation method of the compound, a pharmaceutical composition containing the compound or application of the compound in treatment or prevention of programmed necrosis of cells and/or human receptor interacting protein 1 kinase (RIPK1) related diseases or symptoms. 本发明提供了一类细胞程序性坏死抑制剂及其制备方法和用途。具体地，本发明提供了一种化合物，或其药学上可接受的盐、水合物或溶剂化物，其中，所述的化合物如式I所示。本发明还提供可该化合物的制备方法以及含其的药物组合物或其在治疗或预防与细胞程序性坏死和/或人受体相互作用蛋白1激酶(RIPK1)相关的疾病或病症中的用途。