Detection method of oxaggolil intermediate

The invention relates to a method for detecting an enantiomer of an intermediate 3-[(2R)-2-amino-2-phenethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl) phenyl] methyl]-6-methyl-2, 4-dioxa-1 (1H, 3H)-pyrimidinedione or a salt of the intermediate 3-[(2R)-2-amino-2-phenethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl) phenyl] methyl]-6-methyl-2, 4-dioxa-1 (1H, 3H)-pyrimidinedione. Specifically, the invention relates to detection and separation by high performance liquid chromatography after derivatization by using a derivatization reagent. The method is low in detection cost, high in sensitivity and high in specificity, enantiomers in the intermediate or the salt thereof can be effectively detected and separated, and the quality of a final product is controlled and guaranteed from the source. 本发明涉及噁拉戈利中间体3-[(2R)-2-氨基-2-苯乙基]-5-(2-氟-3-甲氧基苯基)-1-[[2-氟-6-(三氟甲基)苯基]甲基]-6-甲基-2,4-二氧杂-1(1H,3H)-嘧啶二酮或其盐的对映异构体检测方法，具体涉及使用衍生试剂衍生后采用高效液相色谱进行检测分离。本发明检测成本低、灵敏度高、专属性强，能够有效检测分离前述中间体或其盐中对映异构体，从源头