Drying method of enoxaparin sodium intermediate
The invention relates to the technical field of medicines, and provides a drying method of an enoxaparin sodium intermediate, which comprises the following steps: S1, preparation: respectively dissolving heparin sodium and benzethonium chloride with water, and mixing to generate a benzethonium chlor...
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| creator | QIE ZHENGGANG YANG WENPENG GAO SHUHUA ZHANG SUYAN ZHANG GUANGHUI ZHAO HUANRONG |
| description | The invention relates to the technical field of medicines, and provides a drying method of an enoxaparin sodium intermediate, which comprises the following steps: S1, preparation: respectively dissolving heparin sodium and benzethonium chloride with water, and mixing to generate a benzethonium chloride suspension; s2, standing and settling: conveying the benzethonium chloride suspension into an overturning type filtering, washing and drying machine, and standing for 1-10 hours; s3, filtering: filtering under 0.1 to 0.7 MPa to obtain a filter cake; s4, filter cake crushing: raising the temperature to 40-70 DEG C, controlling the vacuum degree of the cavity to be-0.7 to-1.0 Mpa, and inclining to enable the filter cake on the filter plate to fall off and be crushed; s5, rotary vacuum drying: rotating the turnover type filtering, washing and drying machine at the temperature of 40-70 DEG C and the pressure of-0.7 to-1.0 Mpa, and drying a filter cake; and S6, repeating the step S5 until the total rotary vacuum dry |
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s2, standing and settling: conveying the benzethonium chloride suspension into an overturning type filtering, washing and drying machine, and standing for 1-10 hours; s3, filtering: filtering under 0.1 to 0.7 MPa to obtain a filter cake; s4, filter cake crushing: raising the temperature to 40-70 DEG C, controlling the vacuum degree of the cavity to be-0.7 to-1.0 Mpa, and inclining to enable the filter cake on the filter plate to fall off and be crushed; s5, rotary vacuum drying: rotating the turnover type filtering, washing and drying machine at the temperature of 40-70 DEG C and the pressure of-0.7 to-1.0 Mpa, and drying a filter cake; and S6, repeating the step S5 until the total rotary vacuum dry</description><language>chi ; eng</language><subject>BLASTING ; CHEMISTRY ; COMPOSITIONS BASED THEREON ; DERIVATIVES THEREOF ; DRYING ; DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM ; HEATING ; LIGHTING ; MECHANICAL ENGINEERING ; METALLURGY ; ORGANIC MACROMOLECULAR COMPOUNDS ; 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s2, standing and settling: conveying the benzethonium chloride suspension into an overturning type filtering, washing and drying machine, and standing for 1-10 hours; s3, filtering: filtering under 0.1 to 0.7 MPa to obtain a filter cake; s4, filter cake crushing: raising the temperature to 40-70 DEG C, controlling the vacuum degree of the cavity to be-0.7 to-1.0 Mpa, and inclining to enable the filter cake on the filter plate to fall off and be crushed; s5, rotary vacuum drying: rotating the turnover type filtering, washing and drying machine at the temperature of 40-70 DEG C and the pressure of-0.7 to-1.0 Mpa, and drying a filter cake; and S6, repeating the step S5 until the total rotary vacuum dry</description><subject>BLASTING</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>DERIVATIVES THEREOF</subject><subject>DRYING</subject><subject>DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM</subject><subject>HEATING</subject><subject>LIGHTING</subject><subject>MECHANICAL ENGINEERING</subject><subject>METALLURGY</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>POLYSACCHARIDES</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><subject>WEAPONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNB3KarMzEtXyE0tychPUchPU0jNy69ILEgsysxTKM5PySzNVcjMK0ktyk1NyUwsSeVhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoaGZkaG5uamRo7GxKgBAEqPKzo</recordid><startdate>20230606</startdate><enddate>20230606</enddate><creator>QIE ZHENGGANG</creator><creator>YANG WENPENG</creator><creator>GAO SHUHUA</creator><creator>ZHANG SUYAN</creator><creator>ZHANG GUANGHUI</creator><creator>ZHAO HUANRONG</creator><scope>EVB</scope></search><sort><creationdate>20230606</creationdate><title>Drying method of enoxaparin sodium intermediate</title><author>QIE ZHENGGANG ; 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s2, standing and settling: conveying the benzethonium chloride suspension into an overturning type filtering, washing and drying machine, and standing for 1-10 hours; s3, filtering: filtering under 0.1 to 0.7 MPa to obtain a filter cake; s4, filter cake crushing: raising the temperature to 40-70 DEG C, controlling the vacuum degree of the cavity to be-0.7 to-1.0 Mpa, and inclining to enable the filter cake on the filter plate to fall off and be crushed; s5, rotary vacuum drying: rotating the turnover type filtering, washing and drying machine at the temperature of 40-70 DEG C and the pressure of-0.7 to-1.0 Mpa, and drying a filter cake; and S6, repeating the step S5 until the total rotary vacuum dry</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BLASTING CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF DRYING DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM HEATING LIGHTING MECHANICAL ENGINEERING METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES THEIR PREPARATION OR CHEMICAL WORKING-UP WEAPONS |
| title | Drying method of enoxaparin sodium intermediate |
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