Cordycepin monohydrate crystal and preparation method thereof

The invention belongs to the field of medicine refining, and particularly relates to a cordycepin monohydrate crystal and a preparation method thereof. A cordycepin monohydrate crystal form I crystal is obtained from a cordycepin mixed solution to be purified containing dissolved cordycepin through ultrasonic coupling mixed binary solvent cooling crystallization, ultrasonic coupling anti-solvent crystallization or ultrasonic coupling reaction crystallization; or the cordycepin monohydrate crystal form II crystal is obtained from a cordycepin mixed solution to be purified containing dissolved cordycepin through anti-solvent crystallization. Compared with two known anhydrous crystal forms reported at present, the cordycepin monohydrate crystal containing crystal water prepared by the preparation method disclosed by the invention is beneficial to slowing down disintegration and dissolution of cordycepin and prolonging the disintegration and release time of cordycepin tablets because the internal hydrogen-bond in