5-bromine-8-hydroxyquinoline cobalt complex with high anticancer activity as well as synthesis method and application of 5-bromine-8-hydroxyquinoline cobalt complex

The invention discloses a 5-bromine-8-hydroxyquinoline cobalt complex with high anticancer activity as well as a synthesis method and application of the 5-bromine-8-hydroxyquinoline cobalt complex. According to the invention, 5-bromo-8-hydroxyquinoline is used as an active ligand to synthesize the 5-bromo-8-hydroxyquinoline cobalt complex [Co (BrQ) 3]. CH3OH with high anticancer activity, and activity and toxicity experiments of the 5-bromo-8-hydroxyquinoline cobalt complex on human ovarian cancer drug-resistant strain cells SK-OV-3/DDP and normal HL-7702 cells are investigated. Experimental results show that [Co (BrQ) 3]. CH3OH has a very obvious inhibition effect on ovarian cancer drug-resistant strain cells SK-OV-3/DDP, the IC50 value is as low as 0.27 +/-0.09 [mu] M and is far greater than H-BrQ, CoCl2. 6H2O and a clinical drug cis-platinum, and the [Co (BrQ) 3]. CH3OH has low toxicity on normal HL-7702 cells, so that the complex has good tumor selectivity on tumor cells. 本发明公开了高抗癌活性的5-溴-8-羟基喹啉钴配合物及其合成方法和