Remedies for diabetes

本发明涉及含有下面通式：∴[式中，A环以及取代基R#+[1]～R#+[4]如权利要求的范围所定义]所示的2-(N-氰基亚氨基)噻唑烷-4-酮衍生物及其溶剂化物或其药学上可允许的盐为有效成份的糖尿病治疗剂。 This invention relates to therapeutic agents for diabetes comprising a 2-(N-cyanoimino)thiazolidine-4-one derivatives represented by formula I or a solvate or a pharmaceutically acceptable salt thereof as an active ingredient: wherein ring A represents a benzene ring, a condensed ring, or a heterocyclic ring, each of which may be substituted by one or more substituents selected from a straight or branched C1-C4 alkyl group, a haloalkyl group, a halogen atom or -OR , R represents a single bond, an oxygen atom, a sulfur atom, a methyne group, a straight. or branched C1 - C4 alkylene or alkenylene group optionally substituted by a phenyl group, R -X, X-R , X-R -X, R -X-R , -C(=O)-NR - or -NR -C(=O)-, R and R are the same or different and each represents a hydrogen atom, a C1 - C4 alkyl group, -OR or a halogen atom, R represents a hydrogen atom or a C1 - C4 alkyl group, R represents a hydrogen atom or a C1 - C4 alkyl group, R represents a straight or branched C1 - C4 alkylene or alkenylene group, R represents a hydrogen atom or a C1 - C4 alkyl group, R represents a hydrogen atom, a C1 - C4 alkyl group or an aralkyl group, X represents an oxygen atom or a sulfur atom, the configuration of the exocyclic methylene group at 5-position of the thiazolidine ring includes both E- and Z-configuration.