Medicament comprising cppe-loaded PLGA nanoparticles targeted with ANGIOPEP-2 peptides

The present invention provides a cancer drug for the treatment of cancer, wherein phenethyl caffeate (CAPE) is encapsulated in poly [lactic acid-co-glycolic acid] (PLGA) to increase its solubility in an aqueous medium. Angiopep-2 is used as a specific ligand to increase the biological activity. In e...

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Bibliographische Detailangaben
Hauptverfasser:	SERAP. DELMAN, ACAR TAFIN, MANSOOGLU BANU, FATMA. SAIYANBO YARAZ, BOZKURT YAGMUR
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides a cancer drug for the treatment of cancer, wherein phenethyl caffeate (CAPE) is encapsulated in poly [lactic acid-co-glycolic acid] (PLGA) to increase its solubility in an aqueous medium. Angiopep-2 is used as a specific ligand to increase the biological activity. In embodiments of the invention, PLGA is preferably in the form of nanoparticles, thereby ensuring better solubility. 本发明提供了用于治疗癌症的癌症药物，其中咖啡酸苯乙酯(CAPE)被包封在聚[乳酸-共-乙醇酸](PLGA)中以增加其在水性介质中的溶解度。Angiopep-2被用作特异性配体以增加生物活性。在本发明的实施方案中，PLGA优选为纳米颗粒的形式，从而确保更好的溶解度。