Methods of treating cancer using PD-1 axis binding antagonists and anti-GPC3 antibodies

The present disclosure provides compositions and methods for treating cancer. The methods comprise administering a PD-1 axis binding antagonist and an anti-GPC3 antibody. The composition comprises a pharmaceutical composition for use in the treatment of cancer, the pharmaceutical composition compris...

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Hauptverfasser: KATO ATSUHIKO, NARITA YOSHINORI, KINOSHITA YASUKO, ENDO MIKA, ADACHI KENJI, OHTOMO TOSHIHIKO
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The present disclosure provides compositions and methods for treating cancer. The methods comprise administering a PD-1 axis binding antagonist and an anti-GPC3 antibody. The composition comprises a pharmaceutical composition for use in the treatment of cancer, the pharmaceutical composition comprising a PD-1 axis binding antagonist and an anti-GPC3 antibody. Also disclosed are: a pharmaceutical composition comprising an anti-GPC3 antibody as an active ingredient for the treatment of cancer in combination with a PD-1 axis binding antagonist; a pharmaceutical composition for the treatment of cancer in combination with an anti-GPC3 antibody, said pharmaceutical composition comprising a PD-1 axis binding antagonist as an active ingredient. 本公开提供用于治疗癌症的组合物和方法。所述方法包括施用PD-1轴结合拮抗剂和抗GPC3抗体。所述组合物包含用于治疗癌症的药物组合物,所述药物组合物包含PD-1轴结合拮抗剂和抗GPC3抗体。还公开了与PD-1轴结合拮抗剂组合用于治疗癌症的药物组合物,所述药物组合物包含抗GPC3抗体作为活性成分;与抗GPC3抗体组合用于治疗癌症的药物组合物,所述药物组合物包含PD-1轴结合拮抗剂作为活性成分。