Prodrugs of phosphamide nucleotide analogs and pharmaceutical uses thereof

Disclosed are compounds, compositions and methods useful for the treatment of viral infections, such as human immunodeficiency virus (HIV) and/or hepatitis B virus (HBV) infections. Specifically, disclosed are prodrugs of phosphamide nucleotide analogs, methods of preparing the same, and uses of the same as therapeutic agents or prophylactic agents. 本发明公开了可用于治疗病毒感染诸如人免疫缺陷病毒(HIV)和/或乙型肝炎病毒(HBV)感染的化合物、组合物和方法。具体地，公开了膦酰胺核苷酸类似物的前药及其制备方法和作为治疗剂或预防剂的用途。