Liver targeting alkylating agent and application thereof

The invention belongs to the technical field of drug research and development, particularly relates to a cyclophosphamide or ethylene imine prodrug compound, and further discloses application of the cyclophosphamide or ethylene imine prodrug compound in preparation of a liver targeting alkylating agent. According to the compound disclosed by the invention, on the basis of the traditional nitrogen mustard and derivatives and ethylene imine alkylating agents thereof, the compound is subjected to liver drug enzyme metabolism activation in a prodrug form, so that the selectivity of the compound on related compounds is further enhanced, and the influence of the compound on normal cells is reduced; the compound releases active ingredients through metabolism activation of cytochrome P450 (CYP450), and has a good application prospect in the aspect of treating liver-related cancers. 本发明属于药物研发技术领域，具体涉及一种环磷酰胺或乙撑亚胺类前药化合物，并进一步公开其用于制备肝脏靶向烷化剂的用途。本发明所述化合物，在传统氮芥及其衍生物类、乙撑亚胺类烷化剂的基础上，通过前药化的形式，使其经过肝药酶代谢活化，进一步增强了其对相关化合物的选择性，降低其对正常