Raw material impurity of dabigatran etexilate mesylate as well as preparation method and application of raw material impurity

The invention provides a raw material impurity of dabigatran etexilate mesylate, the raw material impurity has a structure as shown in a formula (1), and the invention also provides a preparation method and application of the raw material impurity of dabigatran etexilate mesylate. The invention prov...

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Bibliographische Detailangaben
Hauptverfasser: HUANG GUANGDONG, TAO MINJIE, XU DINGHONG, SHI YUELING, SUN YANG, HE MINHUAN, DONG YULONG, ZHAO FULU
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a raw material impurity of dabigatran etexilate mesylate, the raw material impurity has a structure as shown in a formula (1), and the invention also provides a preparation method and application of the raw material impurity of dabigatran etexilate mesylate. The invention provides detailed information and a preparation method of the raw material impurities of the novel dabigatran etexilate mesylate, the technological process is simple and convenient, a high-purity product which can be used as an impurity reference substance is prepared and further can be used for establishing methods of qualitative, quantitative analysis, detection, purification and the like of the impurities, and the method is suitable for industrial production. The preparation method has very important significance in the aspects of quality control, production process optimization, safety research and the like of the dabigatran etexilate mesylate and the raw materials of the dabigatran etexilate mesylate; 本发明提供了一种甲磺酸达