Method for preparing (2S)-2-[[3-(methylsulfonyl L) phenoxy] methyl] ethylene oxide

The invention provides a method for preparing (2S)-2-[[3-(methylsulfonyl L) phenoxy] methyl] ethylene oxide, and belongs to the field of medicine synthesis. The method comprises the following steps: (1) taking a compound 1 and sodium methanesulfinate as raw materials to react to obtain a compound 2;...

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Hauptverfasser: JIN HAIQUAN, FU SHENGJUN, XU XINGBING, GUO PENG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a method for preparing (2S)-2-[[3-(methylsulfonyl L) phenoxy] methyl] ethylene oxide, and belongs to the field of medicine synthesis. The method comprises the following steps: (1) taking a compound 1 and sodium methanesulfinate as raw materials to react to obtain a compound 2; and (2) taking the compound 2 and (S)-(+)-m-nitrobenzenesulfonic acid glycidyl ester as raw materials to react to obtain a compound 3, namely (2S)-2-[[3-(methylsulfonyl L) phenoxy] methyl] ethylene oxide. The method for preparing the (2S)-2-[[3-(methylsulfonyl L) phenoxy] methyl] ethylene oxide has the advantages of easily available raw materials, mild reaction conditions, simple steps, low cost, safety, no toxicity and easiness in large-scale production, can obviously improve the yield and purity of the target product (2S)-2-[[3-(methylsulfonyl L) phenoxy] methyl] ethylene oxide, and has wide application prospects. 本发明提供了一种制备(2S)-2-[[3-(甲基磺酰基L)苯氧基]甲基]环氧乙烷的方法,属于药物合成领域。所述方法包括以下步骤:(1)以化合物1和甲基亚磺酸钠为原料进行反应,得到化合物2;(2)以化