Biomimetic mineralized silk fibroin scaffold material as well as preparation method and application thereof

The invention relates to the field of biomimetic mineralization and tissue engineering scaffold materials, in particular to a biomimetic mineralization silk fibroin scaffold material and a preparation method and application thereof. The preparation method comprises the following steps: 1) performing induced self-assembly on silk fibroin to obtain a silk fibroin fiber matrix; 2) cross-linking the silk fibroin fibers obtained in the step 1) to obtain a cross-linked silk fibroin fiber mineralization matrix; and 3) mineralizing the cross-linked silk fibroin fiber mineralization matrix obtained in the step 2) in a mineralization solution to obtain the biomimetic mineralization silk fibroin scaffold material. The biomimetic mineralized silk fibroin scaffold material prepared by the preparation method is applied to bone tissue repair. In the invention, the mineralization mode in the silk fibroin fiber simulates the mineralization form of natural bone tissues to a higher extent, and reproduces the surface chemical pr