PD-1 targeted curcumin-loaded nano preparation, preparation and application in kidney diseases

The invention provides a PD-1 targeted curcumin-loaded nano preparation, preparation and application in kidney diseases, and relates to the technical field of biological medicines.The nano preparation is a nano particle of a core-shell structure, the nano preparation structurally comprises a shell, the shell comprises an inner capsule body composed of PLGA and a lipid outer membrane composed of a lipid material, and the inner capsule body and the lipid outer membrane are connected in sequence. The lipid outer membrane wraps the inner capsule body; the inner core is curcumin entrapped in the inner capsule body; and a targeting ligand, wherein the targeting ligand comprises an anti-PD-1 monoclonal antibody for modifying the surface of the nanoparticle. The invention solves the clinical application limitation caused by poor solubility, photodegradation, chemical instability and low bioavailability of curcumin in the prior art. 本发明提供了一种PD-1靶向负载姜黄素的纳米制剂、制备及在肾脏疾病的应用，涉及生物医药技术领域，所述纳米制剂为核壳结构的纳米粒子，其结构包括：外壳，所述外壳包括PLGA构成